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関連する概念動画

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

6.6K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.6K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

5.7K
5.7K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

11.2K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
11.2K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

7.6K
7.6K
Non-gated Ion Channels01:24

Non-gated Ion Channels

7.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.3K
Non-gated Ion Channels01:24

Non-gated Ion Channels

3.6K
3.6K

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Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

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温度に敏感なイオンチャネルを構築する.

Ming-Feng Tsai1, Christopher Miller1

  • 1Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA.

Cell
|August 30, 2014
PubMed
まとめ
この要約は機械生成です。

研究者は温度無感イオンチャネルを冷や熱に反応するように設計した. このタンパク質工学のアプローチは,イオンチャネルにおける温度ゲートと環境への反応性の主要な原理を明らかにします.

さらに関連する動画

One-channel Cell-attached Patch-clamp Recording
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One-channel Cell-attached Patch-clamp Recording

Published on: June 9, 2014

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Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer
10:11

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer

Published on: April 19, 2021

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関連する実験動画

Last Updated: Apr 25, 2026

Controllable Ion Channel Expression through Inducible Transient Transfection
10:00

Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

9.0K
One-channel Cell-attached Patch-clamp Recording
13:07

One-channel Cell-attached Patch-clamp Recording

Published on: June 9, 2014

24.1K
Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer
10:11

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer

Published on: April 19, 2021

3.0K

科学分野:

  • バイオフィジックス 生物物理学
  • 分子生物学は分子生物学である.
  • イオンチャンネル生理学 イオンチャンネル生理学

背景:

  • 温度に敏感なイオンチャネルゲーティングを理解することは,細胞機能にとって極めて重要です.
  • 熱感覚の基礎となる分子機構は,ほとんど未知のままである.
  • ボルテージゲートチャネルには,典型的には固有の温度感度が欠けています.

研究 の 目的:

  • 温度感受性イオンチャネルゲーティングの生体物理的原理を調査する.
  • 熱刺激に反応する温度無感チャネルを設計する.
  • イオンチャネルにおける分子熱感受モデルを開発する.

主な方法:

  • タンパク質工学戦略を利用した.
  • 温度感受性を導入するために,電圧ゲートイオンチャネルを修正しました.
  • 寒さと熱の刺激に反応するチャネルゲーティングの評価.

主要な成果:

  • 温度不敏感のチャネルを冷や熱に反応するよう成功させた.
  • 温度ゲッティングを可能にする重要な構造的または機能的要素を特定した.
  • 熱感覚の分子基礎のための妥当なモデルを確立しました.

結論:

  • タンパク質工学は,イオンチャネルに温度感受性を与えることができます.
  • 温度によるイオンチャネル機能の基本原理を明らかにした.
  • 環境感知の分子メカニズムについての洞察を提供します.