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Updated: Apr 25, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

38.0K

デヒドロピリミジンの蓄積は,上皮-メゼンキマの移行に必要である

Yoav D Shaul1, Elizaveta Freinkman2, William C Comb2

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Cell
|August 30, 2014
PubMed
まとめ

癌細胞は,特定の代謝経路を利用して,攻撃性と転移を高める. 研究者らは,メゼンキマの代謝シグネチャー (MMS) を特定し,二酸化ピリミジン脱水素酵素 (DPYD) が上皮-メゼンキマ移行 (EMT) と腫瘍の拡散に不可欠であることを発見しました.

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