ニューロブラストの時間的なパターンは,HidまたはReaperの調節を通じて,Notch媒介の細胞生存を制御します

Claire Bertet¹, Xin Li¹, Ted Erclik¹

¹Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA.

Cell

|August 30, 2014

まとめ

ドロソフィラの光学葉における一時的なパターンは,神経の多様性を生み出します. 転写因子は,特定のニューロン亜型の原始細胞分裂,ニューロン同一性,プログラム細胞死 (アポトーシス) を制御する.

科学分野:

神経科学は神経科学である.
発達生物学発達生物学について
遺伝学遺伝学とは

背景:

神経細胞の多様性は,中枢神経系の機能に極めて重要です.
神経元祖細胞の時間的なパターニングは,この多様性を生み出すための重要なメカニズムです.

研究の目的:

ドロソフィラの視野葉における一時的なパターンがどのように神経の多様性を生み出しているのかを調査する.
転写因子の祖先分裂,ニューロンの運命,アポトーシスにおける役割を理解する.

主な方法:

外部増殖センター (tOPC) の先端を研究し,ドロソフィラを発達させた.
転写因子の時間表現を分析した.
ノッチ (OFF) ニューロンとノッチ (ON) ニューロンの祖先分裂モードと選択的アポトーシスを研究した.

主要な成果:

tOPCにおける特異的な時系列の転写因子が,連続的なニューロンの生成を統制する.
特定のニューロンのサブタイプの原始細胞分裂モードとアポトーシスは,一時的なパターニングによって制御されます.
Notch (ON) ニューロンはReaper媒介によるアポトーシスを受け,Notch (OFF) ニューロンはHid媒介によるアポトーシスを受けます.

結論:

視野葉におけるニューロン多様性を生み出すには,一時的なパターンが不可欠である.
このプロセスは,ニューロンのアイデンティティを特定し,ニューロンのサブタイプの生存または死亡を調節します.

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