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Updated: Apr 24, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin
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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin

Published on: January 20, 2016

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短いDNA配列は,ヘアピンDNAに強いブレオミシン結合をもたらします

Chenhong Tang1, Ananya Paul, Mohammad P Alam

  • 1Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , Tempe, Arizona 85287, United States.

Journal of the American Chemical Society
|September 5, 2014
PubMed
まとめ

研究者らは,ブレオミシン (BLM) と強く結合し,DNA分裂を促進する特定のDNA配列 (5'-ACGC/5'-GCGT) を特定した. この発見は,強力なBLM-DNA相互作用と分裂機構の重要なモチーフを明らかにしています.

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Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection07:16

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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