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Updated: Apr 24, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

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s(2) U:Aとs(2) U:U塩基対を含むRNA複合体の結晶構造の研究

Jia Sheng1, Aaron Larsen, Benjamin D Heuberger

  • 1Howard Hughes Medical Institute, Center for Computational and Integrative Biology, and Department of Molecular Biology, Simches Research Center, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

Journal of the American Chemical Society
|September 5, 2014
PubMed
まとめ

構造的研究により,2-チオウリジン (s(2) U) がU:Aペアを安定させ,特に1つのU:U構成をRNA複合体で安定させ,おそらくは硫黄結合によるものであることが明らかになった. これは,RNAの改変核塩基に関する新しい洞察を提供します.

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