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Updated: Apr 24, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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腫瘍抑制剤p53のリン酸化トランザクティベーションドメインの拡張弦結合モード

Masahiko Okuda1, Yoshifumi Nishimura

  • 1Graduate School of Medical Life Science, Yokohama City University , 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

Journal of the American Chemical Society
|September 13, 2014
PubMed
まとめ

腫瘍抑制剤p53トランザクティベーションドメイン (TAD) は,驚くべき柔軟性を表しています. リン酸化p53 TAD2は,非リン酸化時の螺旋状構造とは異なるユニークな弦状の方法で標的タンパク質と結合します.

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