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Updated: Apr 23, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

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遺伝子抑制. 遺伝子抑制. H3K27meとPRC2は,世代を超えて,また発達過程で抑圧された記憶を伝達します

Laura J Gaydos1, Wenchao Wang2, Susan Strome3

  • 1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.

Science (New York, N.Y.)
|September 20, 2014
PubMed
まとめ

遺伝子抑制の細胞記憶は,発達に不可欠である. ポリコンブ抑制複合体2 (PRC2) によるヒストンH3 Lys27メチル化 (H3K27me) は,細胞分裂と世代を超えて伝達されます.

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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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