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Updated: Apr 23, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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セストリンは,mTORC1シグナル伝達を制御するRag GTPasesのグアニンヌクレオチド解離阻害剤として機能します

Min Peng1, Na Yin1, Ming O Li1

  • 1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|September 27, 2014
PubMed
まとめ

セストリンはRag GTPasesのグアニンヌクレオチド分裂阻害剤 (GDI) として作用し,栄養素を感知するmTORC1シグナリングを制御します. この発見は,細胞の成長とホメオスタシスの調節のための重要なメカニズムを明らかにします.

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