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CRISPR-Mediated Reorganization of Chromatin Loop Structure
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Rループは,哺乳類の遺伝子ターミネーターの上に抑圧的なクロマチンの痕跡を誘発する

Konstantina Skourti-Stathaki1, Kinga Kamieniarz-Gdula1, Nicholas J Proudfoot1

  • 1Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK.

Nature
|October 9, 2014
PubMed
まとめ

R-ループ,DNA-RNAハイブリッドは,遺伝子終末部位で反意味転写を誘発する. これはRNAの干渉を誘発し,RNAポリメラーゼIIの停止を強化し,遺伝子終結を促進する抑制性ヒストンマークにつながります.

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