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Updated: Apr 22, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

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γ-アミノ酸で,α/γ-ペプチドの12/10ヘリクルの二次構造を好む

Michael W Giuliano1, Stacy J Maynard, Aaron M Almeida

  • 1Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

Journal of the American Chemical Society
|October 11, 2014
PubMed
まとめ

この研究では,ペプチドに交替する水素結合方向性を持つユニークな12/10ヘリクルス構造を強制する新しい周期性ガンマアミノ酸,APCHを導入しました. この独特な形状の好みは,他の制約されたガンマアミノ酸と異なる.

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