Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.3K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.3K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

19.9K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
19.9K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

3.1K
3.1K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

12.9K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
12.9K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

4.9K
4.9K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

11.8K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
11.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target.

Cell reports·2026
Same author

Sustained interferon exposure creates a hyper-metastatic subset of melanoma cells.

bioRxiv : the preprint server for biology·2026
Same author

RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis.

Nature communications·2026
Same author

Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila.

bioRxiv : the preprint server for biology·2026
Same author

The discovery of the mammalian fusome.

eLife·2026
Same author

Leptin Receptor <sup>+</sup> cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14.

bioRxiv : the preprint server for biology·2026

関連する実験動画

Updated: Apr 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

5.7K

タンパク質合成における細胞の差異は,組織ホメオスタシスを調節する.

Michael Buszczak1, Robert A J Signer2, Sean J Morrison2

  • 1Department of Molecular Biology, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|October 11, 2014
PubMed
まとめ
この要約は機械生成です。

タンパク質合成の調節は,細胞の種類によって変化し,細胞のアイデンティティと機能に影響を与えます. これらの細胞特異的な差異は,組織の健康を維持し,腫瘍の予防に不可欠です.

さらに関連する動画

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

18.6K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.1K

関連する実験動画

Last Updated: Apr 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

5.7K
Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

18.6K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.1K

科学分野:

  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.
  • バイオケミストリー バイオケミストリー

背景:

  • タンパク質合成は,しばしば基本的な細胞プロセスと見なされます.
  • しかし,その調節はすべての細胞タイプに均一ではありません.
  • 幹細胞を含む体細胞内のタンパク質合成メカニズムには大きな違いがある.

研究 の 目的:

  • タンパク質合成の細胞型特異的調節を調査する.
  • これらの規制上の差異の機能的影響を理解する.
  • 細胞アイデンティティ,組織ホメオスタシス,腫瘍抑制におけるタンパク質合成調節の役割を調査する.

主な方法:

  • 様々な体細胞のタンパク質合成経路の比較分析.
  • 細胞特異的な分子マーカーを使用して,規制上の違いを特定する.
  • 細胞機能に対するタンパク質合成の調節の影響を調査する.

主要な成果:

  • タンパク質合成における細胞型特異性の有意な変化を示した.
  • 異なる細胞集団におけるタンパク質合成を制御する明確な規制メカニズムを特定した.
  • これらの変異が細胞のアイデンティティと機能を確立し維持する上で果たす重要な役割を示した.

結論:

  • タンパク質合成の調節は高度に専門化されたプロセスであり,普遍的な"家事"機能ではありません.
  • 細胞特異のタンパク質合成の調節は,組織ホメオスタシスと細胞の分化に不可欠です.
  • これらのプロセスの不調は,がんなどの病気に寄与する可能性があります.