オキシトシンは,前頭前皮質内ニューロンの特定のクラスを通して女性の社会性行動を調節します
Miho Nakajima1, Andreas Görlich1, Nathaniel Heintz1
1Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Cell
|October 11, 2014
まとめ
中間前頭前皮質 (mPFC) のオキシトシン (OT) 信号は,社会的行動に影響を与えます. オキシトシン受容体 (OxtrINs) を発現する特定の内部ニューロンは,メスマウスにおける社会的関心の決定的な役割を果たしています.
科学分野:
- 神経科学は神経科学である.
- 社会的行動 社会的行動
- ホルモンのシグナル伝達
背景:
- 鼻内オキシトシン (OT) は,ヒトの前頭皮質を活性化させ,自閉症の脳機能の改善と相関する.
- OTが社会的行動に及ぼす影響を媒介する正確な神経回路は,完全に理解されていません.
研究 の 目的:
- 中間前頭前皮質 (mPFC) 内のオキシトシンシグナル伝達に関与する特定のニューロン集団を特定する.
- 雌マウスの社会行動の調節におけるこれらのニューロンの役割を調査する.
主な方法:
- オキシトシン受容体 (OxtrINs) を発現するソマトスタチン陽性インターニューロンの発見と特徴付け.
- オクストリンを雌マウスのmPFCでオプトジェネティックサイレンシングする.
- mPFC.におけるオキシトシン受容体 (Oxtr) 遺伝子の条件付き削除
- オクストラアンタゴニストの投与.
主要な成果:
- 雌マウスのmPFCにおけるオクストリンを静止することは,雌性サイクルの受容期における雄マウスの社会的関心を特に減少させた.
- この社会性欠陥は,mPFCにおける条件付きOxtr消去とOxtr抗体注入でマウスで再現された.
- これらの発見は,OT/Oxtrシグナル伝達における性別,細胞タイプ,および状態特有の役割を強調しています.
結論:
- オキシトシン/オキシトシン受容体 (OT/Oxtr) のmPFCのシグナル伝達は,OxtrINsによって媒介され,雌マウスの社会性行動の調節に重要な役割を果たします.
- この研究は,複雑な社会的行動の調節に関与する新しい皮質回路要素を特定しています.
- この発見は,社会的機能障害に対する潜在的な治療目標を示唆している.
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