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Updated: Apr 22, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
09:12

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay

Published on: September 10, 2016

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セロトニン-2A GPCRにおける機能的選択性メカニズムは,細胞内ループ2のリガンド依存型構成を含む

Jose Manuel Perez-Aguilar1, Jufang Shan, Michael V LeVine

  • 1Department of Physiology and Biophysics and §The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University , New York, New York 10065, United States.

Journal of the American Chemical Society
|October 15, 2014
PubMed
まとめ

分子動力学シミュレーションは,幻覚誘発性アゴニストと非幻覚誘発性アゴニストとの結合時に,セロトニン2A受容体 (5-HT(2A) R) の明確な構造変化を明らかにします. これらの違い,特に細胞内ループ2の違いは,機能的選択性と異なる精神活性効果を説明する可能性がある.

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