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A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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酵素制御による窒素原子移転により,地域差異性C-Hアミネーションが可能になる

Todd K Hyster1, Christopher C Farwell, Andrew R Buller

  • 1Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.

Journal of the American Chemical Society
|October 18, 2014
PubMed
まとめ

エンジニアリングされたサイトクロームP450BM3 (CYP102A1) 変種は,選択的なC-Hアミネーションを達成します. これらの触媒は地域選択性を制御し,窒素の挿入をベンジルまたはホモベンジルC-H結合に導きます.

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