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Updated: Apr 21, 2026

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

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ミトコンドリア. ミトコンドリア. ミトコンドリア前タンパク質トランスロカゼの細胞周期依存的調節

Angelika B Harbauer1, Magdalena Opalińska2, Carolin Gerbeth3

  • 1Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany. Trinationales Graduiertenkolleg 1478, Universität Freiburg, 79104 Freiburg, Germany. Faculty of Biology, Universität Freiburg, 79104 Freiburg, Germany. BIOSS Centre for Biological Signalling Studies, Universität Freiburg, 79104 Freiburg, Germany.

Science (New York, N.Y.)
|November 8, 2014
PubMed
まとめ

細胞分裂はミトコンドリアの機能を調節する. ミトーシス過程で,Cdk1媒介によるTom6のリン酸化により,ミトコンドリアタンパク質の輸入と組み立てが強化され,呼吸器の活性が促進されます.

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Mitochondrial Protein Sorting01:39

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Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
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Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
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Porin Insertion in the Outer Mitochondrial Membrane

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