人間のライノウイルスの主要な受容体はICAM-1である

J M Greve¹, G Davis, A M Meyer

¹Molecular Therapeutics, Inc., Miles Research Center, West Haven, Connecticut 06516.

Cell

|March 10, 1989

まとめ

科学者たちは,ヒトの主要ライノウイルス受容体を細胞間粘着分子-1 (ICAM-1) として特定しました. この発見は,モノクローナル抗体とタンパク質の配列を解析したもので,ICAM-1が確認された.

科学分野:

ウイルス学ウイルス学ウイルス学
免疫学免疫学とは
細胞生物学細胞生物学

背景:

ヒューマン・ライノウイルスは,風邪の主要な原因です.
ウイルス受容体を特定することは,感染メカニズムを理解し,抗ウイルス戦略を開発するために重要です.

研究の目的:

ヒューマン・ライノウイルスの主要な細胞表面受容体を特定する.
この受容体の分子同一性を特徴付けるために.

主な方法:

モノクローナル抗体を利用して,ライノウイルス受容体を特定し,隔離した.
タンパク質の配列決定とcDNA分析を行いました.
リノウイルスへのインビトロ結合のために,浄化された受容体タンパク質をテストした.

主要な成果:

リノウイルス感染を抑制するモノクローナル抗体は,95 kDaの細胞表面グリコタンパク質を認識した.
95 kDa のタンパク質は精製され,ライノウイルスと結合することが示されました.
タンパク質の配列解析により,受容体は細胞間粘着分子-1 (ICAM-1) と同一であることが明らかになった.

結論:

細胞間粘着分子-1 (ICAM-1) は,ヒトの主要ライノウイルス受容体である.
ICAM-1の遺伝子はヒト染色体19に,他のピコルナウイルス受容体遺伝子の近くに位置しています.

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