p63(+) Krt5(+) 遠隔呼吸道幹細胞は,肺再生に不可欠である

Wei Zuo¹, Ting Zhang¹, Daniel Zheng'An Wu¹

¹Genome Institute of Singapore, A-STAR, 138672 Singapore.

Nature

|November 11, 2014

まとめ

遠隔呼吸道幹細胞 (DASC) は,インフルエンザ感染後の肺組織を再生します. これらの細胞は肺の修復に不可欠であり,肺疾患の治療に役立つ可能性がある.

科学分野:

肺内医学肺内医学肺内医学
再生医学は,再生医療である.
幹細胞生物学幹細胞生物学

背景:

COPDや肺線維症などの慢性肺疾患は,進行的な肺損傷を引き起こす.
現在の治療法は限られており,肺の再生医療には経験的根拠がない.
臨床観察は,重傷後の肺機能の自発的な回復を示唆しています.

研究の目的:

インフルエンザによる損傷後の肺再生における遠隔呼吸道幹細胞 (DASC) の役割を調査する.
DASCが肺修復に不可欠であり,治療目的で使用できるかどうかを判断する.

主な方法:

H1N1インフルエンザ感染後のマウスの肺再生を研究した.
Trp63 (p63) とケラチン5 (DASC ((p63/Krt5)) を発現する遠隔呼吸道幹細胞を特定し,追跡した.
DASCsの選択的アブレーションをin vivoで利用し,DASC移植実験を行った.

主要な成果:

以前存在していたDASC ((p63/Krt5) 細胞は増殖し,インフルエンザによるダメージに反応して新しい胞を形成した.
DASC ((p63/Krt5) の消去は再生を阻害し,線維症と酸素交換の減少につながった.
移植されたDASC ((p63/Krt5) 細胞は,さまざまな肺細胞タイプに微分化し,損傷を軽減しました.

結論:

DASC ((p63/Krt5) 細胞は,ウイルスによる損傷後の肺再生に不可欠です.
これらの細胞は,急性および慢性肺疾患の治療において,細胞ベースの治療法の可能性を秘めています.
文化におけるDASC ((p63/Krt5) の伝播は,治療的応用のための彼らの系統のコミットメントを維持しています.

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