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Updated: Apr 21, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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腫瘍遺伝子の規制について. ノンコーディングのインタージェニック要素の体的変異によって形成された腫瘍性超強化剤

Marc R Mansour1, Brian J Abraham2, Lars Anders2

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6BT, UK.

Science (New York, N.Y.)
|November 15, 2014
PubMed
まとめ

ある種のヒトの癌は,腫瘍遺伝子の発現を誘導するために,スーパーエンハンスターを利用する. この研究では,突然変異がMYB転写因子を勧誘することによって,T細胞急性リンパ性白血病 (T-ALL) で新しいスーパーエンハンスターをどのように生み出すかを明らかにしています.

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