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Updated: Apr 20, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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IAPP主導の代謝再プログラミングは,p53欠乏性腫瘍の回帰を vivo で誘導する

Avinashnarayan Venkatanarayan1, Payal Raulji2, William Norton3

  • 11] Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] Graduate School of Biomedical Sciences, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [4] Metastasis Research Center, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

Nature
|November 20, 2014
PubMed
まとめ

p53ファミリーメンバーp63およびp73をターゲットにすることで,p53-欠乏がんの治療のための新しい戦略が提供されます. 特定のp63/p73の形態を削除すると,腫瘍の成長を抑制するペプチドであるアミリンを上調することで腫瘍の回帰を誘発します.

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