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Updated: Apr 14, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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酸化ヌクレオチドのポリメラーゼ誘発性サイト毒性の発見

Bret D Freudenthal1, William A Beard1, Lalith Perera1

  • 1Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA.

Nature
|November 20, 2014
PubMed
まとめ

酸化ストレスがDNAの構成要素を損傷し,突然変異や病気を引き起こします. この研究は,ヒトのDNAポリメラーゼβが酸化グアニンヌクレオチドを挿入し,DNA損傷と潜在的な細胞死を引き起こす方法を明らかにしています.

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