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Updated: Apr 20, 2026

Mapping Mammalian 3D Genome Interactions with Micro-C-XL
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マウスの調節性DNAの風景は,シス調節性進化のグローバルな原理を明らかにしています

Jeff Vierstra1, Eric Rynes1, Richard Sandstrom1

  • 1Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Science (New York, N.Y.)
|November 21, 2014
PubMed
まとめ

哺乳類のゲノムは,細胞タイプにわたって再利用された保存された転写因子結合部位を持つ,規制DNAの広範な再配線を示しています. この進化は,規制要素の革新,損失,ターンオーバーを伴うが,全体的にTFの拘束サイトを保持している.

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