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DNA Replication02:40

DNA Replication

66.9K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
66.9K
Chromosome Replication02:31

Chromosome Replication

11.2K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
11.2K
The DNA Replication Fork01:02

The DNA Replication Fork

43.7K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
43.7K
The DNA Replication Fork01:02

The DNA Replication Fork

21.9K
21.9K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

64.5K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
64.5K
Replication in Eukaryotes01:29

Replication in Eukaryotes

19.5K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
19.5K

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関連する実験動画

Updated: Apr 20, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
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Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

Published on: January 19, 2017

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人間のDNA複製のタイミングにおける遺伝的多様性

Amnon Koren1, Robert E Handsaker2, Nolan Kamitaki2

  • 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|November 24, 2014
PubMed
まとめ
この要約は機械生成です。

遺伝的変異はDNA複製のタイミングに影響し,変異パターンに影響します. この研究では,複製のタイミングと遺伝子発現を調節し,DNA配列の変異性に影響を与える16の遺伝子位置 (rtQTLs) を特定しました.

さらに関連する動画

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
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Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

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関連する実験動画

Last Updated: Apr 20, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
08:06

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

Published on: January 19, 2017

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Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
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Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

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科学分野:

  • 遺伝学 遺伝学とは
  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.

背景:

  • ゲノムDNAの複製は,特定の時間順に発生し,突然変異の分布に影響を与えます.
  • DNA複製のタイミングの変化の遺伝的根拠は完全に理解されていません.

研究 の 目的:

  • DNA複製のタイミングに対する遺伝的ポリモルフィズムの影響を調査する.
  • 複製のタイミングの変動を制御する遺伝的位置を特定する.

主な方法:

  • 161人の個体 (1000ゲノムプロジェクト) のゲノム配列の読み込み深さを使用して,複製のタイミングの変動を分析しました.
  • 複製タイミングの定量特征局部 (rtQTLs) を特定するために全ゲノム関連研究を行った.

主要な成果:

  • 遺伝アルレルが複製のタイミングと関連している16のrtQTLロキーを特定しました.
  • rtQTLは,複製のタイミングと起源の利用にアレル特異的な効果を示しています.
  • rtQTLsは,メガベーススケールでの遺伝子発現の変動と関連しています.

結論:

  • DNA複製のタイミングは,遺伝的ポリモルフィズムによって大きく左右されます.
  • 遺伝的多形態は,複製のタイミング制御を通じて,近くのDNA配列の変異性を調節する.