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Updated: Apr 20, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

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菌類のポリケチド合成酵素-ペプチド合成酵素ハイブリッドタンパク質の組み合わせ

Thomas B Kakule1, Zhenjian Lin, Eric W Schmidt

  • 1Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.

Journal of the American Chemical Society
|December 2, 2014
PubMed
まとめ

研究者は,ハイブリッド天然産物形成を理解するために,真菌ポリケチド合成酵素 (PKS) と非リボソームペプチド合成酵素 (NRPS) の融合を設計した. 彼らは,新しいPKS-NRPS化合物を成功裏に作るためのルールを確立しました.

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