種全体の遺伝的相容れない分析は,免疫遺伝子を有害なエピスタシスのホットスポットとして識別します
Eunyoung Chae1, Kirsten Bomblies1, Sang-Tae Kim1
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany.
Cell
|December 4, 2014
まとめ
ハイブリッドネクロシスのような遺伝的不一致は,植物免疫受容体の遺伝子相互作用から生じる. これらの相互作用はゲノムホットスポットを作り,病気に対する耐性のための有益なアレル組合せを制限します.
科学分野:
- 植物遺伝学 植物遺伝学
- 進化生物学の進化生物学について
- ゲノミクスゲノミクスとは
背景:
- 異種間遺伝的不適合は,アレル組合せや配列の変異に影響を及ぼします.
- ハイブリッドネクロシスは,植物不適合性であり,遺伝的変異体間のエピスタティック相互作用による自己免疫反応の結果である.
研究 の 目的:
- アラビドプシス・タライアナの遺伝的不適合性ホットスポットを特定するために.
- 植物不適合性における免疫受容体遺伝子の役割を調査する.
主な方法:
- アラビドプシス・タリアナ菌株のF1ハイブリッド数千種を体系的に試験した.
- 不適合性ホットスポットと相互作用する遺伝子を特定するためのゲノム解析.
主要な成果:
- 複数のゲノム相容れないホットスポットが特定され,そのホットスポットはしばしば,核酸結合ドメインと,ルシンの豊富なリピート (NLR) 免疫受容体遺伝子の近くに位置する.
- 免疫受容体位置間の相互作用が観察され,免疫内システム衝突が示唆された.
- DM2 NLR遺伝子クラスターは,様々な遺伝子と相互作用する,重要な不適合性ロカスとして特定されました.
結論:
- 免疫受容体間の有害な相互作用は,植物ゲノム進化の制約として作用する.
- これらの相互作用は,好ましい疾患耐性アレルのアクセシビリティを制限する.
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