耐性慢性咳におけるP2X3受容体アンタゴニスト (AF-219):ランダム化,ダブルブラインド,プラセボ対照第2相試験
Rayid Abdulqawi1, Rachel Dockry1, Kimberley Holt1
1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK.
Lancet (London, England)
|December 4, 2014
まとめ
経口投与のP2X3アンタゴニストであるAF-219は,耐性慢性咳の患者において,咳の頻度を著しく低下させた. この研究は,P2X3受容体アンタゴニストを慢性咳に対する有望な新しい治療法として強調しています.
科学分野:
- 神経科学は神経科学である.
- 薬理学 薬理学とは
背景:
- 呼吸道における状アファレント神経のP2X3受容体は,感覚神経の過敏化に関与している.
- これらの受容体は,咳の反射感受性を媒介し,慢性咳に寄与する可能性があります.
- 耐火性慢性咳は,満たされていない重要な医療ニーズを示しています.
研究 の 目的:
- 新型経口P2X3アンタゴニストであるAF-219の,咳の頻度を減らす効果を評価する.
- 耐火性慢性咳の病理生理学におけるP2X3受容体の役割を調査する.
主な方法:
- ダブルブラインド,プラセボ対照,2期間のクロスオーバー研究が行われました.
- 耐性慢性咳の患者には,AF-219 (600 mg/日2回) またはプラセボを2週間投与し,その後2週間の洗い流し,次に代替治療を受けた.
- 昼間の咳の頻度は,24時間の ambulatory 咳の記録を使用して評価されました.
主要な成果:
- AF-219治療は,プラセボと比較して,咳の頻度が75%減少した (p=0.0003).
- 日中の咳の頻度は,AF-219で37回/hから11回/hに減少しました.
- 味覚障害は,AF-219を投与したすべての患者によって報告され,6回の離脱に至った.
結論:
- P2X3受容体アンタゴニズムは,耐性慢性咳のある患者の咳の頻度を効果的に減少させます.
- AF-219は,抗咳剤の新種としての潜在能力を示しています.
- P2X3受容体へのターゲティングは,咳過敏症に対する有望な治療戦略を提供します.
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