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Updated: Apr 20, 2026

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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デウビキチナゼ DUBAは,T細胞のインタールイキン17の生成に作用する翻訳後のブレーキです

Sascha Rutz1, Nobuhiko Kayagaki2, Qui T Phung3

  • 1Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

Nature
|December 4, 2014
PubMed
まとめ

デウビキチル化酵素DUBAは,Tヘルパー17 (TH17) 細胞のインタールイキン-17A (IL-17A) の生成を抑制する. DUBA欠乏性T細胞は,自己免疫性炎症の悪化を示し,DUBAを重要な調節因子として識別する.

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