中性粒子は活性化された血小板をスキャンして炎症を誘発します

Vinatha Sreeramkumar¹, José M Adrover¹, Ivan Ballesteros²

¹Department of Atherothrombosis, Imaging and Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Science (New York, N.Y.)

|December 6, 2014

まとめ

中性粒子は血小板を巻き込むために偏極化を使用し,PSGL-1のシグナルが炎症中に移動を誘導します. この相互作用は,免疫細胞の密輸と,血栓炎症性損傷の予防に極めて重要です.

科学分野:

免疫学免疫学とは
細胞生物学細胞生物学
血管生物学血管生物学

背景:

白血球の移動は,免疫および炎症反応に不可欠です.
細胞の二極化と非対称な受容体分布は,血管系内の白血球の動きを促進します.

研究の目的:

循環中の活性化された血小板を誘導する中性粒子の偏極化の役割を調査する.
ニュートロフィールと血小板の相互作用に関与するシグナル伝達経路とその移住への影響を解明する.

主な方法:

活性化された静脈における中性粒子の行動の顕微鏡検査.
PSGL-1受容体による信号伝達の分析.
中性粒子の偏極化と移住の欠陥の評価.
血栓炎症性損傷のマウスモデルを用いたインビボ研究.

主要な成果:

中性粒子の二極化は,活性化された血小板を巻き込んだ突起の領域を形成した.
PSGL-1は受容体の再分布を媒介し,中性粒子の移住を促す信号を発信する.
偏極化障害またはPSGL-1シグナル伝達が異常な中性粒子の爬行を引き起こした.
中性粒子と血小板の結合領域をブロックすることで,傷害から保護されます.

結論:

募集された中性粒子は,血流中の活性化された血小板を積極的にスキャンします.
中性粒子の双極性症は,内皮と循環の両方からの信号を統合します.
中性粒子の血小板相互作用をターゲットにすることは,血栓炎症性疾患の潜在的な治療戦略を提供します.

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