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人間化された二重アゴニスト抗体の合理的な設計

Yong Zhang1, Yan Liu, Ying Wang

  • 1California Institute for Biomedical Research (Calibr) , 11119 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|December 11, 2014
PubMed
まとめ

研究者は,ヒトの抗体アゴニストを作成するために,新しい"茎ノブ"抗体構造を設計しました. この汎用性の高いCDR融合戦略により,強力な治療作用を持つ機能的双機能抗体融合タンパク質が成功裏に生成されました.

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