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Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
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アヴェナシオリド:メチチリン耐性黄金のステフィロコクス (MRSA) のペプチドグリカン生物合成に対する潜在的なMurA標的阻害剤

Ching-Ming Chang1, Jeffy Chern, Ming-Yi Chen

  • 1Institute of Biological Chemistry, §Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, #Genomics Research Center, and ▽Agricultural Biotechnology Research Center, Academia Sinica , Taipei 115, Taiwan.

Journal of the American Chemical Society
|December 19, 2014
PubMed
まとめ

菌類からの新しいアベナシオリドは,メチチリン耐性黄色のステフィロコクス (MRSA) に対して強力な活性を示しています. これらの化合物は,MuraAを標的とし,フォスフォマイシン耐性菌株を含む抗生物質耐性細菌に対する新しいアプローチを提供します.

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