関連する実験動画

Updated: Aug 12, 2026

Retroviral Transduction of T-cell Receptors in Mouse T-cells
10:14

Retroviral Transduction of T-cell Receptors in Mouse T-cells

Published on: October 22, 2010

TCR-βの変異遺伝子を持つトランスジェニックマウスのT細胞枯渇

P Krimpenfort1, F Ossendorp, J Borst

  • 1Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam.

Nature
|October 26, 1989
PubMed
まとめ

非機能的なT細胞受容体β (TCR-β) 遺伝子をマウスに導入すると,既存のTCR-β遺伝子の再編成が防止されます. このタンパク質媒介の阻害は,T細胞とB細胞の発達に影響を与え,異なる現象型につながります.

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Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

関連する概念動画

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.