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Updated: Apr 19, 2026

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming
08:56

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Published on: July 30, 2016

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X染色体の再活性化ダイナミクスは,多能性への再プログラミングの段階を明らかにします

Vincent Pasque1, Jason Tchieu2, Rahul Karnik3

  • 1Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Cell
|December 20, 2014
PubMed
まとめ

体細胞を誘発性多能幹細胞 (iPSC) に再プログラムするには,X染色体不活性化を逆転させる必要があります. この研究では,X染色体再活性化 (XCR) 中の連続的な表遺伝子変化が明らかになり,DNA脱メチル化とXistサイレンシングは,忠実な再プログラムに不可欠です.

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