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内心炎の病原体は,活性化された血小板を通して血管内中性粒子の細胞外トラップを誘導することによって,植生形成を促進します

Chiau-Jing Jung¹, Chiou-Yueh Yeh¹, Ron-Bin Hsu¹

¹From the Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-J.J., J.-S.C.); Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.Y., J.-S.C.); Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (R.-B.H.); Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (C.-M.L.); and Department of Forensic Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (C.-T.S.).

|December 21, 2014

まとめ

中性粒子の細胞外トラップ (NET) は,細菌と血小板の集積を相互接続し,捕まえて,内心炎における植物の成長を促します. DNase I処理により,NETsとバクテリアの負荷が低下し,NETsが強調されました.

科学分野:

微生物学微生物学とは
免疫学免疫学とは
心血管研究循環器科の研究

背景:

ストレプトコックは,心内膜炎の際に心臓弁に血小板とともにバイオフィルムを形成します.
植物のバクテリア-血小板集積の閉じ込めを媒介する宿主要因は不明でした.

研究の目的:

内心炎における細菌の植生形成における宿主因子の役割を明らかにする.
バクテリアと血小板の集積の閉じ込めのメカニズムを調査する.

主な方法:

Streptococcus mutans endocarditis のラットモデルを使用しました.
植物の発達における中性粒子の細胞外トラップ (NETs) の役割を調査した.
血管内DNase I予防の影響を評価しました.

主要な成果:

NETは,バクテリアと血小板の集積を植生の中で相互接続し,閉じ込めることを特定しました.
DNase I 治療により,植物の大きさと細菌のコロニー化が著しく減少しました.
活性化された血小板と特定のIgG吸収されたバクテリアは,複数の経路を通じてNET形成を誘導した.
細菌媒介のシグナル伝達経路 (Syk,Src,PI3K,p38 MAPK) は,血小板Pセレクチンを調節し,中性粒子のROS依存性シトルリン化を誘導した.

結論:

中性粒子の細胞外トラップは,内心炎における植生形成の促進と拡大に不可欠です.
NETは支架として機能し,損傷した心弁に細菌・血小板の集積を閉じ込めることを強化します.

キーワード:

血小板 (血小板) とは伝染病は,伝染病である伝染病によって引き起こされる.腸内心臓炎 (エンドカルディティス)中性粒子は中性粒子の

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