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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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(3 + 2) - キャンセルによる機能化された γ-ブチロラクトンのエナチオコンバージェント合成

C Guy Goodman1, Morgan M Walker, Jeffrey S Johnson

  • 1Department of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.

Journal of the American Chemical Society
|December 24, 2014
PubMed
まとめ

この研究は,複雑な分子を作るための動的運動解像度を導入しています. 新しい非対称反応により,3つの正確なステレオセンターを持つガンマ-ブチロラクトンが効率的に生成されます.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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