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関連する概念動画

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

6.4K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
6.4K
Diffusion01:12

Diffusion

232.2K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
232.2K
Diffusion01:21

Diffusion

7.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
7.4K
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

1.9K
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
1.9K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

11.2K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
11.2K
SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

15.2K
Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
15.2K

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関連する実験動画

Updated: Apr 19, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

3.0K

脂質二重層における結合拡散は,近距離接近時に発生する.

Sander Pronk1, Erik Lindahl, Peter M Kasson

  • 1'Department of Theoretical Physics, KTH Royal Institute of Technology , AlbaNova, 106 91 Stockholm, Sweden.

Journal of the American Chemical Society
|December 24, 2014
PubMed
まとめ
この要約は機械生成です。

脂質二重層が近づくにつれて,水の動態は遅くなり,ガラスのようなものになります. この結合は,水素結合によって媒介され,脂質拡散に影響を与え,膜融合プロセスに影響を与える可能性があります.

さらに関連する動画

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.4K

関連する実験動画

Last Updated: Apr 19, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

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SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.4K

科学分野:

  • バイオフィジックス 生物物理学
  • コンピュータ生物学 コンピュータ生物学
  • 膜のダイナミクス

背景:

  • 生物膜のインターフェースは,近くの水の動態を特徴的に遅らせます.
  • 脂質二重層に近づくことは,この効果を強め,膜融合に潜在的に影響を与える.

研究 の 目的:

  • 脂質二重層の接近が脂質と水のダイナミクスに及ぼす影響を調査する.
  • 添付された脂質二重層間の動的結合の基礎となるメカニズムを解明する.

主な方法:

  • 分子ダイナミクスシミュレーションを用いて,2つの接近する脂質二重層をモデル化しました.
  • 分析は,脂質と水の拡散,そして異なる二重層分離における水素結合パターンに焦点を当てた.

主要な成果:

  • 水のダイナミクスは,密接に付着した二重層の間にガラスのような振る舞いを表します.
  • 反対の葉っぱの脂質拡散は,間隔の水層に結合します.
  • ダイナミックカップリングは,増加した脂質-水-脂質-水素結合によって媒介されます.

結論:

  • 膜界面の変化したダイナミクスは,接触を安定させ,膜融合を調節する可能性があります.
  • 観測されたカップリングは,膀-膀融合イベントの前に発生します.
  • 脂質-水-脂質-水素結合は,バイヤー間のダイナミックカップリングを媒介する上で重要な役割を果たします.