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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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単一のタンパク質のサブステキオキオメトリックヒドロキシノニル化により,細胞全体に刺激された抗酸化反応が再現されます

Saba Parvez1, Yuan Fu, Jiayang Li

  • 1Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States.

Journal of the American Chemical Society
|December 30, 2014
PubMed
まとめ

4-hydroxynonenal (HNE) のような脂質由来電離体 (LDEs) で単一のタンパク質を改変すると,重要な細胞反応を誘発することができます. この研究は,一つのターゲットに対するわずかなHNEylationでさえ,抗酸化反応要素 (ARE) を活性化することを示しています.

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