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肺高血圧におけるテロメラーゼの役割

Nathalie Mouraret1, Amal Houssaïni1, Shariq Abid1

  • 1INSERM U955, DHU A-TVB and Département de Physiologie, Hôpital Henri Mondor, Créteil, France and Université Paris-Est Créteil, France (N.M., A.H., S.A., E.M., A.P., G.G.-B., G.D., J.B., L.L., V.A., S.A.); Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium (R.Q., M.D.); Service de Cardiologie, Hôpital Henri Mondor and Université Paris-Est Créteil, Créteil, France (J.-L.D.-R.); and Spanish National Cancer Research Centre (CNIO), Telomeres and Telomerase Group, Madrid, Spain (M.A.B.).

Circulation
|January 1, 2015
PubMed
まとめ

テロメラーゼ逆転写酵素 (TERT) は,肺動脈の滑らかな筋肉細胞 (PA-SMC) の成長を促進することによって,肺高血圧 (PH) を駆動します. TERTを阻害すると,PHが低下し,それが示唆される.

キーワード:
高血圧,肺動脈高血圧などです.筋肉 筋肉 筋肉 筋肉テロメラーゼは,テロメラーゼを血管リモデリング

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