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Updated: Apr 19, 2026

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
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Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST

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フンネル・メタダイナミクスと溶液NMRで,タンパク質・リガンド・アフィニティを推定する

Laura Troussicot1, Florence Guillière, Vittorio Limongelli

  • 1Institut des Sciences Analytiques, UMR 5280, CNRS, Université de Lyon , Université Lyon 1, ENS Lyon -5, rue de la Doua, F-69100 Villeurbanne, France.

Journal of the American Chemical Society
|January 1, 2015
PubMed
まとめ

研究者は,フンネル・メタダイナミクスシミュレーションと溶液核磁気共振 (NMR) 実験を使用して,原子解像度でリガンド-タンパク質の親和性を正確に評価しました. このアプローチは,似たようなリガンドの区別に成功し,分子結合過程の理解を深めました.

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