Vibrio choleraeのタイプVI分泌システムは,水平遺伝子転送を促進しています
Sandrine Borgeaud1, Lisa C Metzger1, Tiziana Scrignari1
1Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Science (New York, N.Y.)
|January 3, 2015
まとめ
Vibrio choleraeのタイプVI分泌システム (T6SS) は,水平遺伝子転送のためのDNAを放出することによって,細菌の進化を助けます. この捕食者を殺すメカニズムは,能力調節器とキチノス表面によって活性化されます.
科学分野:
- 微生物学 微生物学とは
- バクテリアの遺伝学
- ホリゾントル遺伝子転送
背景:
- 自然の能力は,水平遺伝子転送 (HGT) と細菌の進化を容易にする.
- 変換には,DNAの吸収とゲノム統合が含まれます.
- タイプVI分泌システム (T6SS) は,細菌の捕食者を殺す装置として知られています.
研究 の 目的:
- Vibrio cholerae.competence regulonにおけるタイプVI分泌システム (T6SS) の役割を調査する.
- T6SSがDNAのトランスフォーメーションへのアクセシビリティにどのように貢献するのかを理解する.
主な方法:
- 能力規制機関TfoXとQstRによるT6SSをコードする遺伝子クラスター規制の分析.
- チチノス表面での成長時にT6SSの誘導研究.
- T6SS媒介の細胞死とDNA放出を観察するための生細胞画像撮影.
主要な成果:
- T6SS遺伝子クラスターは,能力規制機関であるTfoXとQstRによってポジティブに制御されています.
- T6SSは,Vibrio choleraeがキチン状の表面に成長すると誘発されます.
- 能力介的T6SS誘導は,非免疫細胞を殺し,HGT.のDNAを放出します.
結論:
- T6SSは,Vibrio choleraeの能力規則に統合されています.
- 隣接する細胞のT6SS媒介による殺戮は,変換のためのDNAの可用性を高めます.
- このメカニズムは,細菌の捕食を水平遺伝子転送と進化と結びつける新しい経路を強調しています.
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