1型糖尿病のスコットランド人コホートにおける推定寿命,2008年~2010年
Shona J Livingstone1, Daniel Levin1, Helen C Looker1
1Diabetes Epidemiology Unit, University of Dundee, Dundee, Scotland.
JAMA
|January 7, 2015
まとめ
1型糖尿病 (T1D) の患者は,約11〜13年の平均寿命が失われます. この寿命の大幅な縮小は,不全性心臓病や糖尿病性ケトアシドーシスなどの疾患に関連している.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 公衆衛生は公衆衛生である.
- エピデミオロジー エピデミオロジー
背景:
- 1型糖尿病 (T1D) は歴史的に寿命を短くしています.
- 最近の治療の進歩により,更新された平均寿命の推定値が必要になっています.
研究 の 目的:
- スコットランドのT1DとT1Dのない人の現在の平均寿命を評価する.
- T1D患者の平均寿命の減少に腎臓疾患が唯一の原因であるかどうかを判断する.
主な方法:
- スコットランドのT1D患者24,691人の成人 (≥20歳) を対象とした前向きなコホート研究 (2008年−2010年).
- 人数年数と死亡者数を含む全国の登録データの分析.
- T1DとT1D以外の集団の平均寿命の比較,死因の調査.
主要な成果:
- 20歳になると,T1Dの男性は11.1年,女性は12.9年余命を失います.
- T1Dと正常な腎臓機能を持つ個人でも,寿命が短縮された (男性では8.3年,女性では7.9年).
- 心不全性疾患は,失われた寿命年数の最大の割合 (31-36%) を占め,糖尿病性昏睡/ケトアシドーシスは,早死 (<50歳) に最も寄与しました.
結論:
- スコットランドのT1D (2008年−2010年) は,男性では約11年,女性では20歳で13年の損失と関連しています.
- これらの発見は,T1Dが長寿に及ぼす実質的な影響を,腎臓機能が保たれている場合でも強調しています.
- 心血管疾患と急性合併症は,T1Dでの生存に影響を与える重要な要因であり続けています.
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