喘息と阻害性睡眠時無呼吸症を発症するリスクとの関連
Mihaela Teodorescu1, Jodi H Barnet2, Erika W Hagen2
1James B. Skatrud Pulmonary/Sleep Research Laboratory, William S. Middleton Memorial Veteran's Hospital, Madison, Wisconsin2Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison3Center for Sleep Medicine and Sleep Re.
JAMA
|January 14, 2015
まとめ
喘息は,阻害性睡眠無呼吸症 (OSA) の発症リスクが高いことと関連しています. この研究では,喘息の個人が新発症のOSAを発症する可能性が高く,特に喘息の持続期間が長くなったことを発見しました.
科学分野:
- 呼吸器医学とは
- スリープ・メディシン (睡眠医学)
- エピデミオロジー エピデミオロジー
背景:
- 阻害性睡眠時無呼吸症 (OSA) は,喘息患者で頻繁に観察されていますが,因果関係は不明です.
- 喘息とOSAの発症の関係を理解することは,患者のケアにとって極めて重要です.
研究 の 目的:
- 喘息と阻害性睡眠無呼吸症 (OSA) の発生率の関連性を前向きに調査する.
主な方法:
- 集団ベースの前向きなコホート研究 (ウィスコンシン・スリープ・コホート研究) は,4年の間隔で参加者を追跡した.
- 喘息の状態はアンケートによって評価され,OSAの発生率はポリソムノグラフィによって決定されました.
- 繰り返し測定されたポアソン回帰は,喘息とOSAの関連性を分析するために使用され,混同要因を調整しました.
主要な成果:
- 喘息の参加者は,新たに発症したOSAを発症するリスクが著しく高かった (調整RR,1.39).
- 喘息はまた,習慣的な眠気 (調整RR,2.72) に伴うOSAのリスクの高さとも関連していました.
- 喘息の持続時間が長くなり,OSAと眠気のあるOSAの両方の発生率が増加した.
結論:
- 喘息は,阻害性睡眠時無呼吸症の発症の重要な危険因子です.
- 根本的なメカニズムと,喘息患者のOSAスクリーニングの必要性に関するさらなる研究が推奨されています.
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