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肺高血圧におけるエンドセリアからメゼンキマへの移行

Benoît Ranchoux1, Fabrice Antigny1, Catherine Rucker-Martin1

  • 1From Univ. Paris-Sud, Faculté de médecine, Kremlin-Bicêtre, France (B.R., F.A., C.R.-M., A.H., P.D., F.L., E.F., G.S., M.H., S.C.-K., F.P.); AP-HP, DHU TORINO, Centre de Référence de l'Hypertension Pulmonaire Sévère, Service de Pneumologie et Réanimation Respiratoire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France (B.R., F.A., C.R.-.M., A.H., P.D., F.L., G.S., M.H., S.C.-K., F.P.); INSERM UMR-S 999, Labex LERMIT, Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France (B.R., F.A., C.R.-M., A.H., P.D., F.L., E.F., G.S., M.H., S.C.-K., F.P.); INRA U1196, Génomique et Physiologie de la Lactation - Plateau de Microscopie Electronique à Transmission, Jouy-en-Josas, France (C.P., S.C.); Service de Chirurgie Thoracique, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France (E.F.); Service d'Anatomie Pathologique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., S.P.); Department of Pulmonary Medicine, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands (H.J.B.); INSERM UMR 1064-Center for Research in Transplantation and Immunology-ITUN et Transgenic Rats and Immunophenomic Platform, Nantes, France (S.R., I.A.); and INSERM U955, Département de Physiologie and Service de Cardiologie, Hôpital Henri Mondor, AP-HP, Université Paris-Est Créteil (UPEC), Créteil, France (A.H., S.A.).

Circulation
|January 17, 2015
PubMed
まとめ

内皮からメゼンキマへの移行 (EndoMT) は,BMPR2のシグナル伝達を変えることで,肺動脈高血圧 (PAH) の血管改造に寄与する. このプロセスは薬効性があり,潜在的に新しいPAH治療法を提供します.

キーワード:
TWIST1タンパク質,ヒト骨形態遺伝タンパク質受容体II型心血管疾患 心血管疾患エピテリアル-メゼンキマ移行高血圧,肺動脈高血圧などです.モデル,動物モデル,動物モデルネオインティマスはネオインティマスのことです.シロリムスシロリムス血管リモデリングvimentinin vimentin ヴィメンテニンは,香料として用いられる.

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