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Updated: Apr 18, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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局所的な免疫細胞分解活動に関連した腫瘍の分子および遺伝的特性

Michael S Rooney1, Sachet A Shukla2, Catherine J Wu3

  • 1The Broad Institute, Cambridge, MA 02142, USA; Harvard/MIT Division of Health Sciences and Technology, Cambridge, MA 02141, USA.

Cell
|January 17, 2015
PubMed
まとめ

腫瘍ゲノミクスは,免疫編集を通じて抗腫瘍免疫に影響を与えます. ベータ-2-マイクログローブリン (B2M) とHLA遺伝子の重要な変異は,PD-L1/2の増幅とともに,免疫攻撃に対する腫瘍耐性メカニズムを明らかにします.

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