関連する実験動画

Updated: Apr 18, 2026

Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

9.9K

内皮特異的転写因子Sox17の欠乏は,頭蓋内動脈瘤を誘発する

Seungjoo Lee1, Il-Kug Kim1, Jae Sung Ahn1

  • 1From Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea (S.L., I.-K.K., S.S., G.Y.K., I.K.); Department of Neurological Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea (J.S.A.); Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea (D.-C.W., S.-T.K.); Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea (H.-S.K.); and Department of Physiology, School of Medicine, Chungnam National University, Daejeon, Republic of Korea (B.H.J.).

Circulation
|January 18, 2015
PubMed
まとめ

マウスのSox17欠乏症は,高血圧と併せて,頭蓋内動脈瘤 (IA) を引き起こします. この新しいマウスモデルは,IAの遺伝的要因を明らかにし,この状態のための新しい治療法を開発するためのプラットフォームを提供します.

キーワード:
脳血管疾患など内皮細胞 (endothelial cells) とは,内皮細胞 (endothelial cells) とは,内皮細胞 (endothelial cells) とは,内皮細胞 (endothelial cells) とは,内皮細胞 (endothelial cells) とは,内皮細胞 (endothelial cells) とは,内皮細胞 (endothelial cells) とは,頭蓋内動脈動脈瘤は頭蓋内動脈動脈瘤である.トランスクリプション・ファクター

さらに関連する動画

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

9.0K
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

40.0K

関連する概念動画

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
44.4K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
1