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関連する概念動画

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.3K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.2K
Pigmentation01:19

Pigmentation

5.1K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
5.1K
Skin Cancer01:30

Skin Cancer

6.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.7K
Papillary Dermis01:11

Papillary Dermis

7.0K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
7.0K
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

3.1K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
3.1K

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Direct Reprogramming of Mouse Fibroblasts into Melanocytes
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Vitiligo (ビチリゴ) とは

Khaled Ezzedine1, Viktoria Eleftheriadou2, Maxine Whitton2

  • 1Department of Dermatology and Paediatric Dermatology, National Centre for Rare Skin disorders, Hôpital Pellegrin, Bordeaux, France; Institut National de la Santé et de la Recherche Médicale. U1035, University of Bordeaux, Bordeaux, France.

Lancet (London, England)
|January 19, 2015
PubMed
まとめ
この要約は機械生成です。

Vitiligo は,世界の人口の 1% に影響する一般的な皮膚の色素喪失障害です. 早期診断と心理的影響の理解は,効果的な管理と治療に不可欠です.

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Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Quantification of Hypopigmentation Activity In Vitro
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関連する実験動画

Last Updated: Apr 18, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
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科学分野:

  • 皮膚科 皮膚科について
  • 免疫学 免疫学とは
  • 遺伝学 遺伝学とは

背景:

  • Vitiligo は,世界的に色素の喪失を引き起こす獲得性色素系疾患です.
  • 世界の人口の約1%が罹患していると推定されています.
  • Vitiligoは,特に肌の色が濃い人の場合,重大な心理的苦痛と社会的汚名を引き起こす可能性があります.

研究 の 目的:

  • メラノサイトの喪失を含む白症の臨床的特徴を強調する.
  • 2つの主要な形態であるセグメンタル性および非セグメンタル性白を区別する.
  • 早期治療の重要性を強調し,白症の心理的社会的影響を理解する.

主な方法:

  • 白症の臨床観察と分類について.
  • vitiligoに関する既存の文献のレビュー.
  • 病気の種類に基づいて治療の選択肢と予後についての議論.

主要な成果:

  • Vitiligoは,メラノサイトの損失のために白い斑点として提示します.
  • セグメンタル型と非セグメンタル型である2つの主要な形態は,明確な特徴を持っています.
  • これらの形態を区別することは,適切な治療法を決定し,結果を予測するために非常に重要です.

結論:

  • 白の管理に早期介入は不可欠です.
  • 白症の深い心理社会的影響を理解することは,患者のケアに不可欠です.
  • セグメント性および非セグメント性白症の間では,治療戦略と予後が著しく異なります.