表面皮質と前頭皮質の明確な関係が,証拠の蓄積と関係している
Timothy D Hanks1, Charles D Kopec1, Bingni W Brunton2
11] Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Nature
|January 21, 2015
まとめ
神経調節曲線は,意思決定中に脳の領域に符号化された明確な証拠を明らかにします. 後部頭皮質は,段階的な証拠の蓄積を示し,前部オリエンテーションフィールド (FOF) は,選択のコミットメントのためのカテゴリ信号を使用します.
科学分野:
- 神経科学は神経科学である.
- コグニティブ・サイエンス コグニティブ・サイエンス
- 意思決定のための研究
背景:
- 意思決定は,感覚的証拠の蓄積に依存しています.
- 証拠の蓄積のニューラル相関は,様々な脳の領域で見つかりました.
- 異なる脳領域が意思決定変数をどのようにコードするかを理解することは,非常に重要です.
研究 の 目的:
- 蓄積された証拠に関連したニューラルチューニング曲線を測定するための一般化可能な方法を開発する.
- 決定変数のエンコーディングを,後部頭皮質と前部指向フィールド (FOF) で区分する.
- 意思決定プロセスにおけるFOF活動の因果関係を調査する.
主な方法:
- ネズミの後頭上皮質とFOFにおけるニューロンの発火速度を感知的な意思決定のタスク中に記録した.
- ニューラル応答を分析するために,新しいチューニングカーブアッセイを適用した.
- 試験の異なる段階でFOFの光遺伝的静音化を用い,因果的役割を調査した.
主要な成果:
- 後部頭皮質の神経細胞は,証拠の蓄積を階層的にコードする.
- フロントル・オリエンテーション・フィールド (FOF) のニューロンは,暫定的な決定を反映した,カテゴリ的なエンコーディングを示します.
- 刺激のプレゼンテーションの終わりにFOFのオプトジェネティックサイレンシングは,影響された行動の間にはありません.
結論:
- FOFは,証拠の蓄積ではなく,選択のコミットメントのために決定的な役割を果たします.
- これは,意思決定における前運動皮質の機能に関する既存の見解に異議を唱える.
- 発見は,脳の意思決定の回路論理の洞察を提供します.
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