Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

400
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
400
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

362
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
362
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.4K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.4K
Incomplete Dominance01:43

Incomplete Dominance

29.4K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.4K
Genetic Lingo01:11

Genetic Lingo

113.0K
Overview
113.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same author

Arterial Tissue Gene Expression Associated With Telomere Length Attrition in Coronary Artery Disease.

Journal of lipid and atherosclerosis·2026
Same author

Rare protein-disrupting variants in <i>NPY5R, DLGAP1</i> and <i>MAPK8IP3</i> segregate with OCD in two multiplex pedigrees.

medRxiv : the preprint server for health sciences·2026
Same author

BICEP: an extension to indels and copy number variants for rare variant prioritisation in pedigree analysis.

bioRxiv : the preprint server for biology·2026
Same author

Comparative analysis of pathways induced by TMAO and TNF-α in human microvascular endothelial cells.

Scientific reports·2026
Same author

An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.

Schizophrenia (Heidelberg, Germany)·2026
Same journal

Keep the Hubble and James Webb Space Telescopes alive - the science is worth the price tag.

Nature·2026
Same journal

Say hello to hard helium.

Nature·2026
Same journal

How to avoid dementia - what the science really says.

Nature·2026
Same journal

Save Hubble: the race to preserve the space telescope kicks off.

Nature·2026
Same journal

How long can humans live? All evidence points to a maximum of 125 years.

Nature·2026
Same journal

Listen to Gen Z when it comes to AI in education.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: Dec 13, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.1K

共通する遺伝的変異は,人間の皮質下脳の構造に影響を与えます.

Derrek P Hibar1, Jason L Stein2, Miguel E Renteria3

  • 1Imaging Genetics Center, Institute for Neuroimaging &Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90292, USA.

Nature
|January 22, 2015
PubMed
まとめ
この要約は機械生成です。

遺伝的変異は,ヒトの脳構造,特に皮質下部の領域,例えばパウタメンや尾状核に大きな影響を及ぼします. この研究では,脳の容量に対する新しい遺伝的影響を特定し,発達と神経精神疾患の洞察を提供しました.

さらに関連する動画

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.2K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.1K

関連する実験動画

Last Updated: Dec 13, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.1K
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.2K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.1K

科学分野:

  • 神経遺伝学 神経遺伝学
  • 人間の脳の解剖学 人間の脳の解剖学
  • 分子精神医学は分子精神医学である.

背景:

  • 人間の脳構造は,遺伝的要因によって大きく影響を受けます.
  • 皮質下脳の領域は,運動制御,学習,記憶,および動機付けに不可欠です.
  • 脳回路の障害は,異常な行動や神経疾患に関連しています.

研究 の 目的:

  • 共通遺伝子の変異が7つの脳皮下領域と頭蓋内領域の体積にどのように影響するか調査する.
  • 皮質下脳の構造と関連した新しい遺伝的位置を特定する.
  • 遺伝子変異が脳構造に及ぼす特定の体積効果を理解する.

主な方法:

  • 全ゲノム関連研究 (GWAS) は,磁気共鳴画像 (MRI) データで実施されました.
  • データには,50の独立したコホートから30,717人の個人が含まれていました.
  • 分析は,七つの下皮質領域の体積と頭蓋内体積に焦点を当てた.

主要な成果:

  • プタメンとカウダート核の体積に影響を与える5つの新しい遺伝子変異が特定されました.
  • ヒッポキャンパスと頭蓋内体積と以前に関連していた3つの位置について,より強力な証拠が見つかりました.
  • 変種は,KTN1遺伝子発現に影響するプタメンの体積に最も強い影響を及ぼし,特定の体積効果を示した.

結論:

  • 遺伝的変異は,ヒトの皮質下脳構造の体積調節に特定の役割を果たします.
  • 特定された変異は,ヒトの脳発達の変化性の遺伝的基礎についての洞察を提供します.
  • これらの遺伝的基盤を理解することで,神経精神疾患の機能不全のメカニズムを明らかにすることができます.