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2つの小分子チオールの代謝結合により,リンコマイシンAの生物合成がプログラムされます

Qunfei Zhao1, Min Wang1, Dongxiao Xu1

  • 1State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

Nature
|January 22, 2015
PubMed
まとめ

2つの細菌のチオール,ミコチオール (MSH) とエルゴチオニン (EGT) は,リンコマイシンA抗生物質の生物合成に不可欠です. EGTはテンプレートアセンブリを提供し,MSHは硫黄を提供し,新しいチオール依存の経路を明らかにします.

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