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Updated: Feb 18, 2026

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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トポイソメラーゼI活性によって調節されるリガンド依存増強剤の活性化

Janusz Puc1, Piotr Kozbial1, Wenbo Li1

  • 1Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0648, USA.

Cell
|January 27, 2015
PubMed
まとめ

研究者らは,DNAトポイソメラーゼI (TOP1) によってDNAをニッキングすることが,エンハンサーを活性化させ,エンハンサーRNA (eRNA) を合成するために不可欠であることを発見しました. このプロセスは,ダイヒドロテストステロン (DHT) とアンドロゲン受容体 (AR) によって誘発され,DNA修復機構の採用を伴う.

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