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Updated: Apr 18, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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遅れた鎖の複製は,ゲノムの突然変異の景観を形作る

Martin A M Reijns1, Harriet Kemp1, James Ding1

  • 1MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, UK.

Nature
|January 28, 2015
PubMed
まとめ

新しい研究により,誤差を伴うポリメラーゼ-α (Pol-α) によって合成されたDNAが,突然変異に寄与することが明らかになった. この保存されたDNAは突然変異のホットスポットを形成し,進化と人間の健康に影響を与えます.

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