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抗生物質バイオシンセシス中の非リボソームペプチド合成酵素によるβ-ラクタム形成

Nicole M Gaudelli1, Darcie H Long1, Craig A Townsend1

  • 1Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Nature
|January 28, 2015
PubMed
まとめ

非リボソーム性ペプチド合成酵素はペプチドを組み立て,ノカルディシン抗生物質において重要なベータ・ラクトーム環を形成する. この新しいメカニズムは,他のベータ・ラクタム経路と異なるもので,人工ペプチドの新たな可能性を提供します.

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